Genome Instability and Human Diseases

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Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the fundamental mechanisms of DNA metabolism, including spatial genome organization to genome expression and regulation during development or in response to environmental stress.

The dysfunctions of basic mechanisms linked to genome metabolism underlie human diseases including cancer.


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25 April 2016
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