Cours international

Inter-individual variability of radiation-sensitivity: Mechanisms and Biomarkers - 2013

The course will present the current knowledge on cellular and molecular responses to radiation exposure and how this can be exploited to identify biomarkers for use in molecular epidemiology studies.

During the first week, we will review the molecular consequences of low dose and dose rate exposures to ionising radiation from the generation of oxidative stress and damage at the macromolecular level to long term consequences such as increased cancer risk, with the over-arching theme of individual susceptibility. How mechanistic knowledge can be integrated into molecular epidemiological studies and used to assess individual variation in susceptibility will be presented.

In the second week, students will participate in laboratory sessions on DNA extraction and genotyping techniques, the measurement of DNA repair activity using novel CHIP technology, and the quantification of DNA and protein adducts using different techniques including flow cytometry

Organizers: Janet Hall, Sylvie Chevillard and François Leteurtre

For more information and registration: click here
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Attendance at this training course is open to M2/PhD students, postdoctoral fellows and other interested scientists. All teaching will be in English.
All participants will receive an attestation of presence validated by the University of Paris-Sud 11.

Applications can be made to attend either just the first week of lectures or for both weeks. No applications for just the second week will be considered.

Students will be selected based on their scientific background and motivation to attend the course.

December 9 - 20, 2013
6 November 2013

December 9 - 20, 2013: Lecture sessions held at Institut Curie, Paris
December 16 - 20, 2013: Practical sessions at CEA, near Paris

November 8, 2013

No registration fees are requested

Janet Hall
Sylvie Chevillard
François Leteurtre

Biomolecular Damage and Oxidative Stress
Repair, replication and recombination as biomarkers and use in molecular epidemiological studies
Cell signalling, post-translational modifications and their consequences
Genetic instability and epigenetic changes induced by radiation exposure
Individual susceptibility and logistics of molecular epidemiological studies

DNA repair tests, repair biochips, FACS & genotyping analyses

The course is organized by Institut Curie & CEA in collaboration with the M2 and PhD School of Oncology, University of Paris-Sud 11

European NOE consortium DoReMi