Cours international

Multi-scale integration in biological systems - 2014

Physical description of biological systems, from the single molecule to organisms.

One of the fundamental issues in biology is the understanding of the relationship between the multiple spatial and temporal scales observed in a biological system. From molecules to a cellular function, from a collection of cells to an organism, or from individuals to a population, the complex interactions between singular elements can give rise to “emergent” properties at the ensemble level. To what extent can the spatial and temporal order seen at the system level be explained by subscale properties?

Organizers: M. Coppey, M. Dahan, H. Isambert, P. Martin, P. Silberzan, A. Walczak

Master-2 students, PhD students and postdocs interested in the interface between physics and biology. (The course will provide 3 ECTS at some doctoral schools in Paris, e.g. ED PIF and ED FDV). Students or researchers can also audit the course without receiving credit.

Participants will be selected on the basis of their research interest (CV), motivation statement.
Each participant will give an oral presentation on his/her work or on a research article proposed by the lecturers (20 min + 10 min questions). In addition, each participant will have the opportunity to present a poster which will remain on display during the whole duration of the course.

November 13-18, 2014
21 September 2014

Institut Curie - Paris

No registration fees are requested.
All lunches will be provided by Institut Curie. Participants’ home laboratories are responsible for paying travel and lodging. Institut Curie will pre-booked hotel rooms at preferential rates. A few fellowships will be available upon request and granted to the best presentations.

Mathieu Coppey, Maxime Dahan, Hervé Isambert, Pascal Martin, Pascal Silberzan, Aleksandra Walczak

The course will give an overview of modern physical tools that have been developed to address the issue of scale integration (mornings) and will show how these tools can be applied to specific biological systems (afternoons).

- Statistical physics of out of equilibrium systems / Information theory, inference techniques.
- Non-linear physics, criticality / bistability, switches, oscillations, signal amplification.
- self-organization, collective phenomenon, phase transitions / pattern formation, flocks, cellular
architecture, development.
- evolution, cooperativity and competition / population genetics, evolutionary approach of cancer.

Fondation Pierre-Gilles de Gennes, Labex CelTisPhyBio