International multidisciplinary courses

Systems biology approaches help to analyse molecular mechanisms in silico The diversity across tumors from different patients and even across cancer cells from the same patient makes the picture very complex, making the fundamental aim to find a common mechanism for therapeutic targeting of cancer becomes unpractical. Therefore, the idea of ‘personalized’ or ‘precision’ medicine has been suggested, aiming to find tailored treatment regimen for each patient according to the individual genetic background and tumor molecular profile. This attempt, although ambitious, is achievable thanks to sufficient molecular characterization of cancers accumulated using high-throughput technologies. However, despite availability of cancer high-throughput (omics) data, they are not fully exploited to provide the clue on deregulated mechanisms that would guide better patients stratification and to specific treatment in cancer.

We invited leading speakers from different fields in cancer systems biology, especially from the field of system biology of singe cell data in cancer. The invited speakers will expose various approaches for single cell data analysis and interpretation using cell type-specific pathways resources; tools to study molecular mechanisms of cancer using signalling networks together with omics data from singe cells and to associating it to clinical data. In addition, drug sensitivity prediction algorithms, biomarkers and cancer drivers identification; patient stratification approaches; application of mathematical modelling, machine learning and image analysis in cancer approaches with focus on singe cell data will be demonstrated.

The course will contain the following sessions:

Deciphering and modelling of biological networks involved in cancer

-Cell type-specific pathways resources and comprehensive signalling/metabolic networks and pathway databases in cancer

-Singe cell omics data visualisation, analysis and interpretation in the context of signalling networks and clinical information

-Network inference from single cell data

-Mathematical modelling of cancer molecular mechanisms

High-dimension singe cell and clinical data analysis

-Inferring and analysing tumour heterogeneity from singe cell data

-Prediction of response to treatment

-Singe cell data for more precise patients’ stratification

-Bioimage informatics as high‐Content Screening in singe cell research

-Spatial transcriptomics in organs

In addition to attendance of the lectures, the participants of the course are expected to take part in the following events:

-Presentation of their own scientific project with a flash presentation and a poster (for PhD Students and Post-docs).

-Participation in the Journal Club to present and discuss milestone papers in the cancer systems biology field. Scientific papers within the main topics covered by the course will be sent to the accepted applicants for presentations during the journal club (for Master students).

-Participation in the Career development workshop during the Saturday morning session (all participants).

This course will explore the versatility of non-coding RNAs, a diverse and prevailing class of transcripts that engage in numerous biological processes across every branch of life in all living organisms from bacteria to humans. Word-famous researches will expose their very last discoveries in identification and biogenesis to functional roles of non-coding RNAs in physiology and human disease. It will provide an opportunity to young students and research fellows to discuss their work with an international scientific community in a warm and stimulating environment of Institut Curie.

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The aim of this course is to provide an overview of epigenetic mechanisms and their link to chromatin dynamics. The different functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being developed today. Links between the disruption of nuclear functions and the development of human pathologies will be discussed.

The success of the course relies on the active contribution of participants who are expected to be proactive and to participate in all of the events organized including:
i) presentation of their own scientific project with a poster
ii) participation in the Journal Club to both present and review key articles proposed by the speakers,
iii) participation to the "career development" workshop during the Saturday morning and the "epi-Courses" such as the “Art & Science” workshop.

A special session will be devoted to 2 or 3 alumni who have gone on to successful careers in the field of Epigenetics. Everything is in English.

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In humans, pigment cells comprise the neural crest-derived melanocytes and the pigmented retina cells. Tumor transformation in both cell types results in cutaneous or uveal melanomas, two usually aggressive and hard-to-treat tumour types. 

This course will address the development, the differentiation and the migratory behaviour of melanocytes in embryos and melanoma formation and metastasis in adults. Focus will be made on cellular and molecular mechanisms controlling these processes. The course will then address how advanced imaging technologies, systems biology, and in vivo approaches have progressed in melanoma understanding in the last few years. Finally, some directions for therapeutic approaches will be developped.

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The course aims to address the most recent progress in proton therapy from the multidisciplinary perspective of physics, biology and medicine.


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The aim of this course is to provide an overview of the recent findings and challenges yet to overcome in adolescent and young adults bone and soft tissue sarcomas: from biological characteristics to patient care.
The biology and pathology of sarcomas will be discussed with an emphasis on classification, prognosis, and treatment strategies. European and international directives for patient’s management and care will be reviewed.

The success of the course will rely on the active contribution of the participants who are expected to engage in all the events organized, including the presentation and review of key articles or specific clinical cases/reports during the interactive sessions.

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One of the fundamental issues in biology is the understanding of the relationship between the multiple spatial and temporal scales observed in a biological system. From molecules to a cellular function, from a collection of cells to an organism, or from individuals to a population, the complex interactions between singular elements can give rise to “emergent” properties at the ensemble level. To what extent can the spatial and temporal order seen at the system level be explained by subscale properties?

During this previous course, most seminars were filmed. Discover videos here.

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Institut Curie and Sorbonne Université (SU) organize their 9th International Developmental Biology course.

The programme is proposed in two versions:

- a 5 week-long course including 3 weeks of practicals and 2 weeks of lectures (limited to 18 students)

or
- a 2 week-long version including only the lectures (limited to 35).

Students will present scientific articles related to the topics discussed.

Students and lecturers will have the opportunity to meet during an informal coffee break/lunch every day.

SU grants 12 ECTS for the 5 week-long course and 6 ECTS for the 2 week-long course for the evaluation of the formation.

Practicals : september 17-October 6,2018 (3 weeks)

Lectures: October 8-19, 2018 (2 weeks)

Organizers: A. Bardin, Y. Bellaïche, C. Fournier-Thibault, J.L. Maître, M. Umbhauer

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Systems biology approaches help to analyse molecular mechanisms in silico. Despite availability of cancer high-throughput (omics) and imaging data, they are not fully exploited to provide the clue on deregulated mechanisms that would guide to better patient’s stratification and to specific treatment in cancer and beyond.
We invited leading international speakers from different fields in cancer systems biology that will expose an umbrella of systems biology methods from data analysis to modelling and integration of rationalized treatment schemes into the clinical trials.

>>Click here to register for this course.<<

Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the basic mechanisms of DNA and RNA metabolism, from the spatial genome organization to the chromatin landscape up to the regulation of genome expression during development or in response to genotoxic stress.

The dysfunctions of these basic mechanisms related to genome metabolism underlie human diseases including cancer, aging, neurological disorders and immune deficiency.

Organization:

  • Seminars by experts in the field of the mechanisms that maintain genome stability to large scale approaches (molecular signature using NGS and proteomic). Highlight how a research continuum, from basic research to clinical and translational research, provides opportunities to solve human health issues.
  • Workshops: Carrier development, Scientific communication, Technological workshop, Poster session, “Elevator Pitch”, Students will chair session
  • Poster prize
  • Curie Museum guided visit.


Organizers: Aura Carreira, Chunlong Chen, Valérie Borde, Sarah Lambert