International multidisciplinary courses

One of the fundamental issues in biology is the understanding of the relationship between the multiple spatial and temporal scales observed in a biological system. From molecules to a cellular function, from a collection of cells to an organism, or from individuals to a population, the complex interactions between singular elements can give rise to “emergent” properties at the ensemble level. To what extent can the spatial and temporal order seen at the system level be explained by subscale properties?

During this previous course, most seminars were filmed. Discover videos here.

Organizers: M. Coppey, M. Dahan, H. Isambert, P. Martin, P. Nghe, P. Sens, P. Silberzan, A. Walczak

Systems biology approaches help to analyse molecular mechanisms in silico. Despite availability of cancer high-throughput (omics) and imaging data, they are not fully exploited to provide the clue on deregulated mechanisms that would guide to better patient’s stratification and to specific treatment in cancer and beyond.
We invited leading international speakers from different fields in cancer systems biology that will expose an umbrella of systems biology methods from data analysis to modelling and integration of rationalized treatment schemes into the clinical trials.

>>Click here to register for this course.<<

Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the basic mechanisms of DNA and RNA metabolism, from the spatial genome organization to the chromatin landscape up to the regulation of genome expression during development or in response to genotoxic stress.

The dysfunctions of these basic mechanisms related to genome metabolism underlie human diseases including cancer, aging, neurological disorders and immune deficiency.

Organization:

  • Seminars by experts in the field of the mechanisms that maintain genome stability to large scale approaches (molecular signature using NGS and proteomic). Highlight how a research continuum, from basic research to clinical and translational research, provides opportunities to solve human health issues.
  • Workshops: Carrier development, Scientific communication, Technological workshop, Poster session, “Elevator Pitch”, Students will chair session
  • Poster prize
  • Curie Museum guided visit.


Organizers: Aura Carreira, Chunlong Chen, Valérie Borde, Sarah Lambert

This course is jointly organized by the Institut Curie and the Institut Pasteur in collaboration with ISAC, the International Society for the Advancement of Cytometry, AFC (Association Française de Cytométrie), and Ciphe (Centre d’immunophénomique), Marseille. The workshop will cover basic and advanced cytometry topics and will consist of lectures and practical modules taught by international experts in the field.  

The multicolor track will have a strong focus on advanced panel design and high dimensional data analysis.

To register, click here.

Faculty: P.Chattopadhyay, J.Irish, H.Luche, Y.Saeys, B.Telford, P.Wallace, G.Osborne, D.Hedley, S.Chow, A.Krishan, P.Jain, M.Scheimann, Z.Porat.

Organizers: Z.Maciorowski, Institut Curie, S.Novault & M.Hasan, Institut Pasteur, A.Krishan, University of Miami, USA, T.Kalina, Charles University, Prague, Czech Republic, H.Luche, Ciphe, Marseilles.

This career Development workshop is a unique opportunity for participants, PhD students and young postdocs, to discuss their career objectives with speakers who, after earning a PhD in biology, chose various career paths leading them away from the bench (education, industry, science communication and management, etc…). The workshop is organized in short round-tables, where participants and invited speakers will exchange in an informal way.

Each participant should have the opportunity to discuss with at least 7 speakers.

The course will run from Wednesday afternoon to Wednesday evening of the following week. Each day there will be a different topic and 4-5 lectures from local researches (one 1h long lecture) and foreigner speakers (2 lectures). In the evening, during dinner the students will present their research in the format of 10 minutes chalk talk using a white board and only one Powerpoint slide. There will be also 3 sessions with short talks (10 minutes talk plus 5 minutes questions) from selected abstracts (opened to all researchers in Paris area). To motivate students to interact with speakers, we will assign each speaker to 2 students. Students will be expected to read recent papers from the speaker’s lab, to introduce the speaker, chair questions after his/her talk, and to serve as a guide/host for the speaker during the course.

Courses will be taught in English. While the whole course will be open to everyone, the students’ presentations will be restricted to selected students.

Organizers: Stéphanie Miserey-Lenkei, Guillaume Montagnac, Danijela Vignjevic

This course will explore the versatility of non-coding RNAs, a diverse and prevailing class of transcripts that engage in numerous biological processes across every branch of life in all living organisms from bacteria to humans. Word-famous researches will expose their very last discoveries in identification and biogenesis to functional roles of non-coding RNAs in physiology and human disease. It will provide an opportunity to young students and research fellows to discuss their work with an international scientific community in a warm and stimulating environment of Institut Curie.

The success of the course relies on an active participation of the trainees in discussions and exchange with invited speakers, the poster presentation of their own scientific projects, Journal Clubs by reviewing and presenting key articles in the field chosen by the speakers.

Organizers: D. Bourc'his, E. Heard, A. Londono, A. Morillon, M. Pinskaya, A. Shkumatava, F. Toledo

The aim of this course is to provide an overview of epigenetic mechanisms and their link to chromatin dynamics. The different functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being developed today. Links between the disruption of nuclear functions and the development of human pathologies will be discussed.

The success of the course relies on the active contribution of participants who are expected to be proactive and to participate in all of the events organized including:
i) presentation of their own scientific project with a poster
ii) participation in the Journal Club to both present and review key articles proposed by the speakers,
iii) participation to the "career development" workshop during the Saturday morning and the "epi-Courses" such as the “Art & Science” workshop.

A special session will be devoted to 2 or 3 alumni who have gone on to successful careers in the field of Epigenetics. Everything is in English.

Organizers: Geneviève Almouzni, Nathalie Dostatni

This course in English will immerse students and researchers in an intense collaborative work, stimulating creative thinking for the development of an “out-of-the-box” project. This will be a full week of hard work and fruitful discussion with peers that will encourage the participants to question their pre-established ideas about cell biology.
Eight researchers from France and eight researchers from Chile will be intensely committed to train and guide the students, encouraging them to think in an interdisciplinary and ambitious way. We seek to foster a friendly and collaborative environment that will not only provide top-level training for students, but also promote mutual learning and networking opportunities for all participants.

Organizers: Ana-Maria Lennon and Claire Hivroz (Institut Curie, France), Carolina Torrealba and Betsi Flores (Fundación Ciencia & Vida, Chile)

In humans, pigment cells comprise the neural crest-derived melanocytes and the pigmented retina cells. Tumor transformation in both cell types results in cutaneous or uveal melanomas, two usually aggressive and hard-to-treat tumour types. 

This course will address the development, the differentiation and the migratory behaviour of melanocytes in embryos and melanoma formation and metastasis in adults. Focus will be made on cellular and molecular mechanisms controlling these processes. The course will then address how advanced imaging technologies, systems biology, and in vivo approaches have progressed in melanoma understanding in the last few years. Finally, some directions for therapeutic approaches will be developped. 

In the practical part of this course, the notions developped in the seminars and courses will be illustrated by in vivo manipulations in embryos and in vitro cellular manipulation, both followed by advanced imaging analysis. An opening will be made on other cancers that have similarities with melanoma as medulloblastoma and glioblastoma.