International multidisciplinary courses

This course will explore the versatility of non-coding RNAs, a diverse and prevailing class of transcripts that engage in numerous biological processes across every branch of life in all living organisms from bacteria to humans. Word-famous researches will expose their very last discoveries in identification and biogenesis to functional roles of non-coding RNAs in physiology and human disease. It will provide an opportunity to young students and research fellows to discuss their work with an international scientific community in a warm and stimulating environment of Institut Curie.

Organizers: D. Bourc'his, Ines Drinnenberg, E. Heard, A. Londono, A. Morillon, M. Pinskaya, A. Shkumatava, F. Toledo

One of the fundamental issues in biology is the understanding of the relationship between the multiple spatial and temporal scales observed in a biological system. From molecules to a cellular function, from a collection of cells to an organism, or from individuals to a population, the complex interactions between singular elements can give rise to “emergent” properties at the ensemble level. To what extent can the spatial and temporal order seen at the system level be explained by subscale properties?

During this course, most seminars were filmed. Discover videos here.

Organizers: M. Coppey, M. Dahan, H. Isambert, P. Martin, P. Nghe, P. Sens, P. Silberzan, A. Walczak

The possibility to control at specific time and places the activity of biomolecules is opening up new opportunities in the study of physiological processes at the single cell level in a live organism.
This course will present the requirement for non-invasive optical methods and the development of multi-photon microscopy to control and record biomolecules activity. The course will address how optogenetic tools can be used to record physiological process (sensor) or to control protein activity (actuators).
These techniques at the interface between advanced microscopy, genetics and physics are of interests to numerous research groups at Institut Curie.

Organizers: F. Del Bene & S. Vriz

Institut Curie and Université Pierre et Marie Curie organize their 7th International Developmental Biology course, in collaboration with the Stowers Institute for Medical Sciences, Kansas City, USA.
The programme is proposed in two versions:
- a 5 week-long course including 3 weeks of practicals and 2 weeks of lectures (limited to 18 students)
- a 2 week-long version including only the lectures (limited to 35).
Students will present scientific articles related to the topics discussed.
Students and lecturers will have the opportunity to meet during an informal coffee break/lunch every day.
The UPMC grants 12 ECTS for the 5 week-long course and 6 ECTS for the 2 week-long course.

Practicals: September 19 - October 7, 2016 (3 weeks)
Lectures: October 10 - 21, 2016 (2 weeks)

Organizers: A. Bardin, Y. Bellaïche, C. Fournier-Thibault, J.R. Huynh, M. Umbhauer 

This career Development workshop is a unique opportunity for participants, PhD students and young postdocs, to discuss their career objectives with speakers who, after earning a PhD in biology, chose various career paths leading them away from the bench (education, industry, science communication and management, etc…). The workshop is organized in short round-tables, where participants and invited speakers will exchange in an informal way.

Each participant should have the opportunity to discuss with at least 7 speakers.

Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the fundamental mechanisms of DNA metabolism, including spatial genome organization to genome expression and regulation during development or in response to environmental stress.
The dysfunctions of basic mechanisms linked to genome metabolism underlie human diseases including cancer.

Organizers: A. Carreira, S. Lambert & Pr. S. Saule

For the 8th Edition of the Cytoskeleton course version, we have decided to merge the Cytoskeleton course and the Labex Celtisphybio course since the main topics and interest of these two courses are very similar and that the dates of the courses are very close. The course will be divided into two parts:

Form Wednesday to Saturday, this 1st part follows the spirit of Cytoskeleton: during the day we will have local speakers who will give 1h-2h talks and in the evening the students will present their work.On Saturday, we will organize career development workshop (please see "workshop" here under).

From Monday to Wednesday, the 2nd part follows the spirit of the Labex Celtisphybio course: international speakers will give a 1h talk, and short talks selected from abstracts will be given by participants. Others will present posters in 3 poster sessions.

Organizers: S. Miserey-Lenkei, G. Montagnac, D. Vignjevic

This course will provide an overview of post-transcriptional gene regulations (splicing, polyadenylation, methylation, stability and translation of (pre-) messenger RNAs). It will notably cover molecular mechanisms, genome-wide analyses and implications in cancer (session “RNA towards the clinic”).

This theoretical course is complementary to a practical course held at CRG in Barcelona the following week. Applications for the theoretical and/or practical courses must be made here.

Organizers : M-C. Daugeron, M. Dutertre, S. Vagner

In humans, pigment cells comprise the neural crest-derived melanocytes and the pigmented retina cells. Tumor transformation in both cell types results in cutaneous or uveal melanomas, two usually aggressive and hard-to-treat tumour types. This course will address the development, the differentiation and the migratory behaviour of melanocytes in embryos and melanoma formation and metastasis in adults. Focus will be made on cellular and molecular mechanisms controlling these processes. The course will then address how advanced imaging technologies, systems biology, and in vivo approaches have progressed in melanoma understanding in the last few years. Finally, some directions for therapeutic approaches will be developped.
In the practical part of this course, the notions developped in the seminars and courses will be illustrated by in vivo manipulations in embryos and in vitro cellular manipulation, both followed by advanced imaging analysis.

Organizers: A-H. Monsoro-Burq, S. Saule, P. Pla, C. Borday, L. Méry, F. Coquelle

The aim of the course is to stimulate high level discussions around Cell Biology (Cell migration and mechanics, cytoskeleton dynamics, epigenetics, immunological synapses, developmental biology, membrane trafficking, system biology, neurobiology, biophysics) and particularly, to think about how the study of the cell has reshaped and gained insight from diverse disciplines, particularly physics, and new technologies. This discussion will be the guiding line during this one-week course, where we will have seminars from the sixteen participating scientists as well as eight working groups, each composed of five graduate students that will be co-guided by a Chilean and a French researcher in the development of a research project.

We deeply thank The Company of Biologists who has made a donation to this course.

Organizers: Ana-Maria Lennon, Claire Hivroz and Carolina Torrealba (Chile)