International multidisciplinary courses

This career Development workshop is a unique opportunity for participants, PhD students and young postdocs, to discuss their career objectives with speakers who, after earning a PhD in biology, chose various career paths leading them away from the bench (education, industry, science communication and management, etc…). The workshop is organized in short round-tables, where participants and invited speakers will exchange in an informal way.

Each participant should have the opportunity to discuss with at least 7 speakers.

Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the fundamental mechanisms of DNA metabolism, including spatial genome organization to genome expression and regulation during development or in response to environmental stress.
The dysfunctions of basic mechanisms linked to genome metabolism underlie human diseases including cancer.

Organizers: A. Carreira, S. Lambert & Pr. S. Saule

For the 8th Edition of the Cytoskeleton course version, we have decided to merge the Cytoskeleton course and the Labex Celtisphybio course since the main topics and interest of these two courses are very similar and that the dates of the courses are very close. The course will be divided into two parts:

Form Wednesday to Saturday, this 1st part follows the spirit of Cytoskeleton: during the day we will have local speakers who will give 1h-2h talks and in the evening the students will present their work.On Saturday, we will organize career development workshop (please see "workshop" here under).

From Monday to Wednesday, the 2nd part follows the spirit of the Labex Celtisphybio course: international speakers will give a 1h talk, and short talks selected from abstracts will be given by participants. Others will present posters in 3 poster sessions.

Organizers: S. Miserey-Lenkei, G. Montagnac, D. Vignjevic

This course will provide an overview of post-transcriptional gene regulations (splicing, polyadenylation, methylation, stability and translation of (pre-) messenger RNAs). It will notably cover molecular mechanisms, genome-wide analyses and implications in cancer (session “RNA towards the clinic”).

This theoretical course is complementary to a practical course held at CRG in Barcelona the following week. Applications for the theoretical and/or practical courses must be made here.

Organizers : M-C. Daugeron, M. Dutertre, S. Vagner

In humans, pigment cells comprise the neural crest-derived melanocytes and the pigmented retina cells. Tumor transformation in both cell types results in cutaneous or uveal melanomas, two usually aggressive and hard-to-treat tumour types. This course will address the development, the differentiation and the migratory behaviour of melanocytes in embryos and melanoma formation and metastasis in adults. Focus will be made on cellular and molecular mechanisms controlling these processes. The course will then address how advanced imaging technologies, systems biology, and in vivo approaches have progressed in melanoma understanding in the last few years. Finally, some directions for therapeutic approaches will be developped.
In the practical part of this course, the notions developped in the seminars and courses will be illustrated by in vivo manipulations in embryos and in vitro cellular manipulation, both followed by advanced imaging analysis.

Organizers: A-H. Monsoro-Burq, S. Saule, P. Pla, C. Borday, L. Méry, F. Coquelle

The aim of the course is to stimulate high level discussions around Cell Biology (Cell migration and mechanics, cytoskeleton dynamics, epigenetics, immunological synapses, developmental biology, membrane trafficking, system biology, neurobiology, biophysics) and particularly, to think about how the study of the cell has reshaped and gained insight from diverse disciplines, particularly physics, and new technologies. This discussion will be the guiding line during this one-week course, where we will have seminars from the sixteen participating scientists as well as eight working groups, each composed of five graduate students that will be co-guided by a Chilean and a French researcher in the development of a research project.

We deeply thank The Company of Biologists who has made a donation to this course.

Organizers: Ana-Maria Lennon, Claire Hivroz and Carolina Torrealba (Chile)

One of the major goals of this course is to give an overview of potential impact of the non coding part of the genome during the cell life. This covers not only regulatory non-coding RNAs, but also unknown ncRNAs such as those emerging from repetitive sequences, both playing a crucial role in the expression and maintenance of the genomes.The course will describe the biogenesis pathways of different ncRNAs, as well as the mechanisms of gene regulation and genome defence implicating these RNAs. It will cover recent achievements in ncRNA detection, emerging findings of novel ncRNA species in the context of development, cellular differentiation and human diseases.

Organizers: D. Bourc'his, E. Heard, A. Londono, A. Morillon, M. Pinskaya, A. Shkumatava,  F. Toledo

The aim of this course is to provide an overview of epigenetic mechanisms and their link to chromatin dynamics. The different functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being developed today. Links between the disruption of nuclear functions and the development of human pathologies will be discussed.

The success of the course relies on the active contribution of participants who are expected to be proactive and to participate in all of the events organized including:
i) presentation of their own scientific project with a poster
ii) participation in the Journal Club to both present and review key articles proposed by the speakers,
iii) participation to the "career development" workshop during the Saturday morning and the "epi-Courses" such as the “Art & Science” workshop.

A special session will be devoted to 2 alumni who have gone on to successful careers in the field of Epigenetics.

Organizers: Geneviève Almouzni, Nathalie Dostatni

The possibility to control at specific time and places the activity of biomolecules is opening up new opportunities in the study of physiological processes at the single cell level in a live organism.

This course will present the requirement for non-invasive optical methods and the development of multi-photon microscopy to control and record biomolecules activity. The course will address how optogenetic tools can be used to record physiological process (sensor) or to control protein activity (actuators).

These techniques at the interface between advanced microscopy, genetics and physics are of interests to numerous research groups at Institut Curie.

The aim of this course (theory and practice) of 4 weeks is to attract an international group of students (Master students and young PhD students) to this research area by bringing together leading scientists for a series of state-of the-art lectures and cutting edge practical sessions. The practical course provides training in cell culture of transfected and infected cells, in vitro reconstitution of cellular functions, gene inactivation, and introduces students to cutting edge techniques of live imaging. Every week a specific theme is tackled and talks and experiments alternate.

Course description on Institut Pasteur's site
Registration on Institut Pasteur's site
Organizers: Roberto Bruzzone, Philippe Chavrier, Chiara Zurzolo