International multidisciplinary courses

One of the fundamental issues in biology is the understanding of the relationship between the multiple spatial and temporal scales observed in a biological system. From molecules to a cellular function, from a collection of cells to an organism, or from individuals to a population, the complex interactions between singular elements can give rise to “emergent” properties at the ensemble level. To what extent can the spatial and temporal order seen at the system level be explained by subscale properties?

Organizers: M. Coppey, M. Dahan, H. Isambert, P. Martin, P. Silberzan, A. Walczak

Institut Curie and Université Pierre et Marie Curie organize their 5th International Developmental Biology course in collaboration with the Regenerative and Developmental Biology programme of Harvard University and the Stowers Institute for Medical sciences of Kansas City from September 22 to October 24, 2014.
Practicals: September 22 - October 10, 2014 (3 weeks)
Lectures: October 13 - 24, 2014 (2 weeks)

Organizers: Allison Bardin, Yohanns Bellaïche, Claire Fournier-Thibault, Jean-René Huynh, Muriel Umbhauer

The 6th European Course of in vivo Preclinical Assays in Cancer Therapy is an extensive training program designed to educate and update the biomedical research community on current trends and technological advances in in vivo preclinical assays in cancer.
The emphasis of this course will be on the use of genetically engineered mouse models and patient-derived xenograft (PDX) models for in vivo preclinical research.
The course will cover the following topics: in vitro preclinical assays employing established tumor cell lines and functional genomics approaches, preclinical imaging, angiogenesis and metastasis, Zebrafish model, therapy resistance models and approaches, ethics and co-clinical trials.

Organizers: Virginie Dangles-Marie, Elisabetta Marangoni, Jos Jonkers (NKI), Sven Rottenberg (NKI)

Registration (form and steps below)

The general objective of this course is to understand the role of the cytoskeleton in cell interaction with the microenvironment at different levels: molecular, cellular and in the living organism. The course will provide introductions to the main cytoskeleton networks as well as to the physical and biochemical properties of extracellular matrices. It will cover general mechanisms of cell interaction with the matrix, migration and invasion in relevant microenvironment with a more particular focus on the role of cytoskeleton-based organelles in these basic cellular functions.

Organizers: Danijela Vignjevic and Guillaume Montagnac

Key to the proper inheritance of the genetic information, cells should duplicate their genome before mitosis and avoid mutagenesis.

The course will describe the mechanisms and the regulation that ensures the maintenance of genetic information across cell generations. An emphasis will be put on:

initiation and completion of replication along the bulk chromosomes and at specific regions such as the telomeres and fragile sites; the pathways of DNA repair and recombination; the relationships linking replication stress to the formation of DNA damage; the signalling events surrounding intrinsic and environmentally induced DNA damage; the interference with transcriptional activity; the variety of cellular responses to damage including the generation of chromosome rearrangements and oncogenesis.

A large set of experimental methods involving genetic, molecular, cellular, and biochemical approaches will be taught.

Organizers : Alain Nicolas, Franck Toledo, Michelle Debatisse, Arturo Londono-Vallejo

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Cell biology applied to different biological systems: Cell migration and mechanics, cytoskeleton dynamics, epigenetics, ER dynamics, Golgi structure and function, immune synapse, long RNAs in development biology, membrane trafficking, mitochondrial function, neurobiology, UPR and ER stress.

Organizers: Ana-Maria Lennon, Claire Hivroz, Patricia Burgos, Gonzalo Mardones (Chile)


One of the major goals of this course is to give an overview of potential impact of the non coding part of the genome during the cell life. This covers not only regulatory non-coding RNAs, but also unknown ncRNAs such as those emerging from repetitive sequences, both playing a crucial role in the expression and maintenance of the genomes.The course will describe the biogenesis pathways of different ncRNAs, as well as the mechanisms of gene regulation and genome defence implicating these RNAs. It will cover recent achievements in ncRNA detection, emerging findings of novel ncRNA species in the context of development, cellular differentiation and human diseases.

Organizers: Déborah Bourc'his, Edith Heard, Arturo Londono, Antonin Morillon, Marina Pinskaya, Alena Shkumatava, Franck Toledo.

In the second week, students will participate in laboratory sessions on DNA extraction and genotyping techniques, the measurement of DNA repair activity using novel CHIP technology, and the quantification of DNA and protein adducts using different techniques including flow cytometry

Organizers: Janet Hall, Sylvie Chevillard and François Leteurtre

For more information and registration: click here
or complete the form available below and send it to: studentsdoremi2013@curie.fr

The aim of this course is to provide an overview of epigenetic mechanisms and their link to chromatin dynamics. The different functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being developed today. Links between the disruption of nuclear function and the development of human pathologies will be discussed.

Organizers: Geneviève Almouzni, Nathalie Dostatni

In humans, pigment cells comprise the neural crest-derived melanocytes and the pigmented retina cells. Tumor transformation in both cell types results in cutaneous or uveal melanomas, two usually aggressive and hard-to-treat tumour types. This course will address the development, the differentiation and the migratory behaviour of melanocytes in embryos and melanoma formation and metastasis in adults. Focus will be made on cellular and molecular mechanisms controlling these processes. The course will then address how advanced imaging technologies, systems biology, and in vivo approaches have progressed in melanoma understanding in the last few years. Finally, some directions for therapeutic approaches will be developped.
In the practical part of this course, the notions developped in the seminars and courses will be illustrated by in vivo manipulations in embryos and in vitro cellular manipulation, both followed by advanced imaging analysis.

Organizers: Anne. H. Monsoro-Burq, Patrick Pla, Simon Saule, Morgane Locker, Odile Bronchain, Frederic Coquelle

Registration: click here