International multidisciplinary courses

One of the major goals of this course is to give an overview of potential impact of the non coding part of the genome during the cell life. This covers not only regulatory non-coding RNAs, but also unknown ncRNAs such as those emerging from repetitive sequences, both playing a crucial role in the expression and maintenance of the genomes.The course will describe the biogenesis pathways of different ncRNAs, as well as the mechanisms of gene regulation and genome defence implicating these RNAs. It will cover recent achievements in ncRNA detection, emerging findings of novel ncRNA species in the context of development, cellular differentiation and human diseases.

Organizers: Déborah Bourc'his, Edith Heard, Arturo Londono, Antonin Morillon, Marina Pinskaya, Alena Shkumatava, Franck Toledo.

In the second week, students will participate in laboratory sessions on DNA extraction and genotyping techniques, the measurement of DNA repair activity using novel CHIP technology, and the quantification of DNA and protein adducts using different techniques including flow cytometry

Organizers: Janet Hall, Sylvie Chevillard and François Leteurtre

For more information and registration: click here
or complete the form available below and send it to: studentsdoremi2013@curie.fr

The aim of this course is to provide an overview of epigenetic mechanisms and their link to chromatin dynamics. The different functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being developed today. Links between the disruption of nuclear function and the development of human pathologies will be discussed.

Organizers: Geneviève Almouzni, Nathalie Dostatni

In humans, pigment cells comprise the neural crest-derived melanocytes and the pigmented retina cells. Tumor transformation in both cell types results in cutaneous or uveal melanomas, two usually aggressive and hard-to-treat tumour types. This course will address the development, the differentiation and the migratory behaviour of melanocytes in embryos and melanoma formation and metastasis in adults. Focus will be made on cellular and molecular mechanisms controlling these processes. The course will then address how advanced imaging technologies, systems biology, and in vivo approaches have progressed in melanoma understanding in the last few years. Finally, some directions for therapeutic approaches will be developped.
In the practical part of this course, the notions developped in the seminars and courses will be illustrated by in vivo manipulations in embryos and in vitro cellular manipulation, both followed by advanced imaging analysis.

Organizers: Anne. H. Monsoro-Burq, Patrick Pla, Simon Saule, Morgane Locker, Odile Bronchain, Frederic Coquelle

Registration: click here

La 4e réunion annuelle des spécialistes des Cellules Tumorales Circulantes aura lieu le mardi 24 septembre 2013 à l'Institut Curie à Paris. Une vingtaine d'orateurs échangeront sur leurs thématiques de pointe, tant sur les résultats que sur les projets à venir.


Cette réunion se déroulera juste avant la 9e édition de l' International Symposium on Minimal Residual Cancer" du 25 au 27 septembre à l'hôtel Pullmann Bercy - Paris 12e.
Ce congrès abordera les thèmes de la recherche sur le processus métastatique et sur leurs applications cliniques. Nous espérons que les chercheurs et cliniciens de l'institut Curie seront nombreux à y participer.

Inscription 4e Réunion Annuelle GFCTC - 24 septembre 2013 : cliquer ici

Institut Curie and UPMC organize their 4th International Developmental Biology course in collaboration with the Regenerative and Developmental Biology programme of Harvard University and the Stowers Institute for Medical sciences of Kansas City from September 23 to October 25, 2013.
Practicals: September 23 - October 12, 2013 (3 weeks)
Lectures: October 14 - 25, 2013 (2 weeks)

Organizers: Claire Fournier-Thibault, Muriel Umbhauer, Yohanns Bellaïche, Jean-René Huynh

This European Course has been organised with the European Network for Teenagers and Young Adults with Cancer (ENTYAC) and will discuss the global approach to taking care of TYA cancer patients. Points of discussion include: - a multi-professional, pan-European point of view, including paediatric and adult cancer and health care specialists - an exchange of information between clinical and biological approaches. We aim to better understand and compare the multi-disciplinary and international approaches which can improve clinical practice and patient care.


Organizers: Valérie Laurence - François Doz -  Sue Morgan - Riccardo Riccardi - Dan Stark - Laurence Brugières

The general objective of this course is to understand the role of the cytoskeleton in cell functions at different levels: molecular, cellular and in the living organism. The course will introduce all three cytoskeleton networks: actin, microtubules and intermediate filaments. The course will cover general mechanisms of cell migration, cell polarity and cell division focusing on the role of cytoskeleton-dependent trafficking and cytoskeleton-based organelles such as the centrosome.
Lecturers and participants will be both physicists and biologists. Conferences will be in English. Each day will include four-five one-hour lectures and participant presentations in English.

Organizers: Danijela Vignjevic, Guillaume Montagnac

Key to the proper inheritance of the genetic information, cells should duplicate their genome before mitosis and avoid mutagenesis. The course will describe the mechanisms and the regulations that ensure the maintenance of genetic information across cell generations. Focus will be put on initiation and completion of replication along the bulk chromosomes and at specific regions such as the telomeres ; the pathways of DNA repair and recombination ; the relationships linking replication stress to the formation of DNA damages ; the signalling of intrinsic and environmentally induced DNA damages ; the interferences with the transcriptional activity ; the variety of cellular responses to damages including the generation of chromosome rearrangements and oncogenesis. A large set of experimental methods involving genetic, molecular, cellular, biochemical approaches will be taught.

Organizers: Michelle Debatisse, Alain Nicolas, Franck Toledo, Members of Unit IC/CNRS UMR3244/UPMC

 

This course will address the development, the differentiation and the migratory behaviour of melanocytes in embryos and melanoma formation and metastasis in adults. Focus will be made on cellular and molecular mechanisms controlling these processes. The course will then address how advanced imaging technologies, systems biology, and in vivo approaches have progressed in melanoma understanding in the last few years. Finally, some directions for therapeutic approaches will be developped. In the practical part of this course, the notions developped in the seminars and courses will be illustrated by in vivo manipulations in embryos and in vitro cellular manipulation, both followed by advanced imaging analysis.

Organizers: Anne-Hélène Monsoro-Burq, Simon Saule, Fabrice Cordelières, Morgane Locker, Odile Bronchain, Frédérique Coquelle