International multidisciplinary courses

For the fifth year, the  European  course  of  ‘in  vivo  Preclinical  Assays  in  Cancer  Therapy’ is  jointly organized with the NKI in Amsterdam. The Symposium on Preclinical Assays in Cancer Therapy is an extensive training program designed to educate and update the biomedical research community on current  trends  and  technological  advances  in vivo  preclinical  assays  in  cancer. 

Organizers: Sven Rottenberg (NKI), Jos Jonkers (NKI), Elisabetta Marangoni (Institut Curie), Virginie Dangles-Marie (Institut Curie)

Cell biology applied to different biological systems: Immunology, Host-Pathogen Interactions, cytoskeletal remodeling, phagocytosis and autophagy, mitotic spindle formation.

Organizers: Ana-Maria Lennon, Claire Hivroz, Ariel Savina, Matias Ostrowski (Argentine)

One of the major goals of this course is to give an overview of potential impact of the non coding part of the genome during the cell life. This covers not only regulatory non-coding RNAs, but also unknown ncRNAs such as those emerging from repetitive sequences, both playing a crucial role in the expression and maintenance of the genomes.The course will describe the biogenesis pathways of different ncRNAs, as well as the mechanisms of gene regulation and genome defence implicating these RNAs. It will cover recent achievements in ncRNA detection, emerging findings of novel ncRNA species in the context of development, cellular differentiation and human diseases.

Organizers: Déborah Bourc’his, Edith Heard, Marta Kwapisz, Arturo Londono, Antonin Morillon, Marina Pinskaya, FranckToledo

Uveal melanoma course with ophthalmological aspects including diagnosis, differential diagnosis and local treatments. The course will include recent biological advances and a review of the possible oncological treatments.

Organizers: Laurence Desjardins, Sophie Piperno-Neumann, Jérôme Couturier, Sarah Coupland

The general objective of this course is to understand the role of the cytoskeleton in cell migration and invasion at different levels: molecular, cellular and in the living organism. The course will cover general mechanism of cell migration in 2D and 3D substrates; different modes of migration such as single and collective cell migration; and it will provide the examples of normal cell migration during tissue morphogenesis and invasion migration of cancer cells.
Lecturers and participants will be both physicists and biologists. Conferences will be in English. Each day will include five one hour lectures plus participant presentations.

Organizers: Guillaume Montagnac, Danijela Vignjevic

Key to the proper inheritance of the genetic information, cells should duplicate their genome before mitosis and avoid mutagenesis. The course will describe the mechanisms and the regulations that ensure the maintenance of genetic information across cell generations. Focus will be put on initiation and completion of replication along the bulk chromosomes and at specific regions such as the telomeres ; the pathways of DNA repair and recombination ; the relationships linking replication stress to the formation of DNA damages ; the signalling of intrinsic and environmentally induced DNA damages ; the interferences with the transcriptional activity ; the variety of cellular responses to damages including the generation of chromosome rearrangements and oncogenesis. A large set of experimental methods involving genetic, molecular, cellular, biochemical approaches will be taught.

Organizers: Michelle Debatisse, Franck Toledo, Alain Nicolas

This course will address the development, the differentiation and the migratory behaviour of melanocytes in embryos and melanoma formation and metastasis in adults. Focus will be made on cellular and molecular mechanisms controlling these processes. The course will then address how advanced imaging technologies, systems biology, and in vivo approaches have progressed in melanoma understanding in the last few years. Finally, some directions for therapeutic approaches will be developped. In the practical part of this course, the notions developped in the seminars and courses will be illustrated by in vivo manipulations in embryos and in vitro cellular manipulation, both followed by advanced imaging analysis.

Organizers: Anne-Hélène Monsoro-Burq, Patrick Pla, Simon Saule, Morgane Locker, Odile Bronchain

The aim of this course is to provide an overview of the epigenetic mechanisms and their link to chromatin dynamics. The different functions of the nucleus involving the genome and its organization will be discussed with an emphasis on the technological limits and the new experimental approaches developed today. Links between the disruption of nuclear function and the development of human pathologies will be discussed.

Organizers: Geneviève Almouzni and Nathalie Dostatni

This course focuses on the cell shape changes that occur during cell motility and embryonic development, with an emphasis on the physical mechanisms involved in these biological processes. Lecturers and participants will be both physicits and biologists. Conferences will be in English.

Organizers: Cécile Sykes and Julie Plastino

The aim of this course (theory and practice) of 4 weeks is to attract an international group of students (Master students and youg PhD students) to this research area by bringing together leading scientists for a series of state-of the-art lectures and cutting edge practical sessions. The practical course provides training in cell culture of transfected and infected cells, in vitro reconstitution of cellular functions, gene inactivation, and introduces students to cutting edge techniques of live imaging. Every week a specific theme is tackled and talks and experiments alternate.

Course description and programme  on the website of the Institut Pasteur.

Organizers: Roberto Bruzzone, Philippe Chavrier, Chiara Zurzolo