International multidisciplinary courses

One of the major goals of this course is to give an overview of potential impact of the non coding part of the genome during the cell life. This covers not only regulatory non-coding RNAs, but also unknown ncRNAs such as those emerging from repetitive sequences, both playing a crucial role in the expression and maintenance of the genomes.The course will describe the biogenesis pathways of different ncRNAs, as well as the mechanisms of gene regulation and genome defence implicating these RNAs. It will cover recent achievements in ncRNA detection, emerging findings of novel ncRNA species in the context of development, cellular differentiation and human diseases.

Organizers: D. Bourc'his, E. Heard, A. Londono, A. Morillon, M. Pinskaya, A. Shkumatava,  F. Toledo

The aim of this course (theory and practice) of 4 weeks is to attract an international group of students (Master students and young PhD students) to this research area by bringing together leading scientists for a series of state-of the-art lectures and cutting edge practical sessions. The practical course provides training in cell culture of transfected and infected cells, in vitro reconstitution of cellular functions, gene inactivation, and introduces students to cutting edge techniques of live imaging. Every week a specific theme is tackled and talks and experiments alternate.

Course description and programme on the website of the Institut Pasteur's site.
Organizers: Roberto Bruzzone, Philippe Chavrier, Chiara Zurzolo

During the first week, we will review the molecular consequences of low dose and dose rate exposures to ionising radiation from the generation of oxidative stress and damage at the macromolecular level to long term consequences such as  increased cancer risk, with the over-arching theme of individual susceptibility. How mechanistic knowledge can be integrated into molecular epidemiological studies and used to assess individual variation in susceptibility will be presented. In the second week students will participate in laboratory sessions on DNA/RNA extraction and genotyping techniques, the quantification of DNA and protein adducts, DNA repair activity and cell senescence using Fluorescent Activated Cell Sorting (FACS) and immunofluorescence.

Organizers : Janet Hall, Sylvie Chevillard and François Leteurtre

For more information and registration
: click here or contact organizers at: 

The aim of this course is to provide an overview of epigenetic mechanisms and their link to chromatin dynamics. The different functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being developed today. Links between the disruption of nuclear functions and the development of human pathologies will be discussed.

The success of the course relies on the active contribution of participants who are expected to be proactive and to participate in all of the events organized including:
i) presentation of their own scientific project with a poster
ii) participation in the Journal Club to both present and review key articles proposed by the speakers,
iii) participation to the "career development" workshop during the Saturday morning and the "epi-Courses" such as the “Art & Science” workshop.

A special session will be devoted to 3 alumni students who have gone on to successful careers in the field of Epigenetics.

Organizers: Geneviève Almouzni, Nathalie Dostatni

One of the fundamental issues in biology is the understanding of the relationship between the multiple spatial and temporal scales observed in a biological system. From molecules to a cellular function, from a collection of cells to an organism, or from individuals to a population, the complex interactions between singular elements can give rise to “emergent” properties at the ensemble level. To what extent can the spatial and temporal order seen at the system level be explained by subscale properties?

Organizers: M. Coppey, M. Dahan, H. Isambert, P. Martin, P. Silberzan, A. Walczak

Institut Curie and Université Pierre et Marie Curie organize their 5th International Developmental Biology course in collaboration with the Regenerative and Developmental Biology programme of Harvard University and the Stowers Institute for Medical sciences of Kansas City from September 22 to October 24, 2014.
Practicals: September 22 - October 10, 2014 (3 weeks)
Lectures: October 13 - 24, 2014 (2 weeks)

Organizers: Allison Bardin, Yohanns Bellaïche, Claire Fournier-Thibault, Jean-René Huynh, Muriel Umbhauer

The 6th European Course of in vivo Preclinical Assays in Cancer Therapy is an extensive training program designed to educate and update the biomedical research community on current trends and technological advances in in vivo preclinical assays in cancer.
The emphasis of this course will be on the use of genetically engineered mouse models and patient-derived xenograft (PDX) models for in vivo preclinical research.
The course will cover the following topics: in vitro preclinical assays employing established tumor cell lines and functional genomics approaches, preclinical imaging, angiogenesis and metastasis, Zebrafish model, therapy resistance models and approaches, ethics and co-clinical trials.

Organizers: Virginie Dangles-Marie, Elisabetta Marangoni, Jos Jonkers (NKI), Sven Rottenberg (NKI)

Registration (form and steps below)

The general objective of this course is to understand the role of the cytoskeleton in cell interaction with the microenvironment at different levels: molecular, cellular and in the living organism. The course will provide introductions to the main cytoskeleton networks as well as to the physical and biochemical properties of extracellular matrices. It will cover general mechanisms of cell interaction with the matrix, migration and invasion in relevant microenvironment with a more particular focus on the role of cytoskeleton-based organelles in these basic cellular functions.

Organizers: Danijela Vignjevic and Guillaume Montagnac

Key to the proper inheritance of the genetic information, cells should duplicate their genome before mitosis and avoid mutagenesis.

The course will describe the mechanisms and the regulation that ensures the maintenance of genetic information across cell generations. An emphasis will be put on:

initiation and completion of replication along the bulk chromosomes and at specific regions such as the telomeres and fragile sites; the pathways of DNA repair and recombination; the relationships linking replication stress to the formation of DNA damage; the signalling events surrounding intrinsic and environmentally induced DNA damage; the interference with transcriptional activity; the variety of cellular responses to damage including the generation of chromosome rearrangements and oncogenesis.

A large set of experimental methods involving genetic, molecular, cellular, and biochemical approaches will be taught.

Organizers : Alain Nicolas, Franck Toledo, Michelle Debatisse, Arturo Londono-Vallejo

Registration: click here

Cell biology applied to different biological systems: Cell migration and mechanics, cytoskeleton dynamics, epigenetics, ER dynamics, Golgi structure and function, immune synapse, long RNAs in development biology, membrane trafficking, mitochondrial function, neurobiology, UPR and ER stress.

Organizers: Ana-Maria Lennon, Claire Hivroz, Patricia Burgos, Gonzalo Mardones (Chile)