International multidisciplinary courses

Institut Curie and Université Pierre et Marie Curie organize their 6th International Developmental Biology course in collaboration with the Stowers Institute for Medical sciences of Kansas City from September 21 to October 23, 2015.

Practicals: September 21 - October 9, 2015 (3 weeks)
Lectures: October 12 - 23, 2015 (2 weeks)

Organizers: Allison Bardin, Yohanns Bellaïche, Claire Fournier-Thibault, Jean-René Huynh, Muriel Umbhauer

Major advances in basic research of melanoma have led to novel treatment options that are making a difference for melanoma patients. However, multiple challenges lie ahead and further progress is necessary, particularly with respect to resistance to the novel therapies. For advancing knowledge in the area and to ensure that future scientists are updated with respect to current knowledge in the field, we will host a course which teaches the basic biology and develoment of the melanocyte how these cells are transformed into melanoma, and how the disease is diagnosed and treated. A particular emphasis will be on novel therapeutic options and the resistance that arises against the new drugs.

The course is divided into two sessions, both will be held at the University of Iceland, in Reykjavik.
. 1st session: course (June 21-23) - register on Institut Curie website
. 2nd session: meeting (June 24-26) - register on the following website:

The general objective of this course is to understand the role of the cytoskeleton in intracellular trafficking and cell migration at different levels: molecular, cellular and in the living organism. The course will provide introductions to the main cytoskeleton networks as well as to the basic mechanisms of trafficking and migration regulation. It will cover general mechanisms though which intracellular trafficking controls cell migration and invasion with a more particular focus on the role of cytoskeleton-based organelles in these basic cellular functions. Lecturers and participants will be both physicists and biologists. Conferences will be in English. Each day will include four-five one hour lectures plus participant presentations.

In humans, pigment cells comprise the neural crest-derived melanocytes and the pigmented retina cells. Tumor transformation in both cell types results in cutaneous or uveal melanomas, two usually aggressive and hard-to-treat tumour types. This course will address the development, the differentiation and the migratory behaviour of melanocytes in embryos and melanoma formation and metastasis in adults. Focus will be made on cellular and molecular mechanisms controlling these processes. The course will then address how advanced imaging technologies, systems biology, and in vivo approaches have progressed in melanoma understanding in the last few years. Finally, some directions for therapeutic approaches will be developped.
In the practical part of this course, the notions developped in the seminars and courses will be illustrated by in vivo manipulations in embryos and in vitro cellular manipulation, both followed by advanced imaging analysis.

Organizers: A-H. Monsoro-Burq, S. Saule, P. Pla, C. Borday, M. Locker, F. Coquelle

The aim of this course is to provide an overview of post-transcriptional gene regulations at multiple steps, including notably (pre-)messenger RNA splicing, polyadenylation, stability and translation. This course will particularly address 3 aspects: underlying molecular mechanisms, genome-wide analyses of post-transcriptional regulatory networks and the involvement in cancer, with a special session entitled “RNA towards the clinic”.

One of the major goals of this course is to give an overview of potential impact of the non coding part of the genome during the cell life. This covers not only regulatory non-coding RNAs, but also unknown ncRNAs such as those emerging from repetitive sequences, both playing a crucial role in the expression and maintenance of the genomes.The course will describe the biogenesis pathways of different ncRNAs, as well as the mechanisms of gene regulation and genome defence implicating these RNAs. It will cover recent achievements in ncRNA detection, emerging findings of novel ncRNA species in the context of development, cellular differentiation and human diseases.

Organizers: D. Bourc'his, E. Heard, A. Londono, A. Morillon, M. Pinskaya, A. Shkumatava,  F. Toledo

The aim of this course (theory and practice) of 4 weeks is to attract an international group of students (Master students and young PhD students) to this research area by bringing together leading scientists for a series of state-of the-art lectures and cutting edge practical sessions. The practical course provides training in cell culture of transfected and infected cells, in vitro reconstitution of cellular functions, gene inactivation, and introduces students to cutting edge techniques of live imaging. Every week a specific theme is tackled and talks and experiments alternate.

Course description and programme on the website of the Institut Pasteur's site.
Organizers: Roberto Bruzzone, Philippe Chavrier, Chiara Zurzolo

During the first week, we will review the molecular consequences of low dose and dose rate exposures to ionising radiation from the generation of oxidative stress and damage at the macromolecular level to long term consequences such as  increased cancer risk, with the over-arching theme of individual susceptibility. How mechanistic knowledge can be integrated into molecular epidemiological studies and used to assess individual variation in susceptibility will be presented. In the second week students will participate in laboratory sessions on DNA/RNA extraction and genotyping techniques, the quantification of DNA and protein adducts, DNA repair activity and cell senescence using Fluorescent Activated Cell Sorting (FACS) and immunofluorescence.

Organizers : Janet Hall, Sylvie Chevillard and François Leteurtre

For more information and registration
: click here or contact organizers at: 

The aim of this course is to provide an overview of epigenetic mechanisms and their link to chromatin dynamics. The different functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being developed today. Links between the disruption of nuclear functions and the development of human pathologies will be discussed.

The success of the course relies on the active contribution of participants who are expected to be proactive and to participate in all of the events organized including:
i) presentation of their own scientific project with a poster
ii) participation in the Journal Club to both present and review key articles proposed by the speakers,
iii) participation to the "career development" workshop during the Saturday morning and the "epi-Courses" such as the “Art & Science” workshop.

A special session will be devoted to 3 alumni students who have gone on to successful careers in the field of Epigenetics.

Organizers: Geneviève Almouzni, Nathalie Dostatni

One of the fundamental issues in biology is the understanding of the relationship between the multiple spatial and temporal scales observed in a biological system. From molecules to a cellular function, from a collection of cells to an organism, or from individuals to a population, the complex interactions between singular elements can give rise to “emergent” properties at the ensemble level. To what extent can the spatial and temporal order seen at the system level be explained by subscale properties?

Organizers: M. Coppey, M. Dahan, H. Isambert, P. Martin, P. Silberzan, A. Walczak