Cours international

Genome Instability and Human Disease - 2018

Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the basic mechanisms of DNA and RNA metabolism, from the spatial genome organization to the chromatin landscape up to the regulation of genome expression during development or in response to genotoxic stress.
The dysfunctions of these basic mechanisms related to genome metabolism underlie human diseases including cancer, aging, neurological disorders and immune deficiency.

Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the basic mechanisms of DNA and RNA metabolism, from the spatial genome organization to the chromatin landscape up to the regulation of genome expression during development or in response to genotoxic stress.

The dysfunctions of these basic mechanisms related to genome metabolism underlie human diseases including cancer, aging, neurological disorders and immune deficiency.

Organization:

  • Seminars by experts in the field of the mechanisms that maintain genome stability to large scale approaches (molecular signature using NGS and proteomic). Highlight how a research continuum, from basic research to clinical and translational research, provides opportunities to solve human health issues.
  • Workshops: Carrier development, Scientific communication, Technological workshop, Poster session, “Elevator Pitch”, Students will chair session
  • Poster prize
  • Curie Museum guided visit.


Organizers: Aura Carreira, Chunlong Chen, Valérie Borde, Sarah Lambert

Master student, PhD, Post-doc, researcher

Selection on CV and recommendation letter.
30 places.

From May 28 to June 1, 2018
15 April 2018

Institut Curie
Amphitheater BDD
11-13, rue Pierre & Marie Curie
75005 Paris - France

April 30, 2018

No registration fees are requested

- Aura Carreira, unité UMR3348 « Stress génotoxiques et cancer », chef d’équipe « Recombinaison Homologue et Cancer », Institut Curie, Orsay.
- Chunlong Chen, unité UMR3344 « Dynamique de l’information génétique », chef d’équipe « Programme de Réplication et instabilité du génome », Institut Curie, Paris.
- Valérie Borde, unité UMR3344 « Dynamique de l’information génétique », chef d’équipe « Dynamique des chromosomes et recombinaison », Institut Curie, Paris.
- Sarah Lambert, unité UMR3348 « Stress génotoxiques et cancer », chef d’équipe « Recombinaison, Réplication et Stabilité des Génomes », Institut Curie, Orsay.

This international course has two objectives:
- Gain knowledge of mechanisms ensuring genome stability, from fundamental molecular pathways (DNA replication, repair, transcription, genome organization) up to large scale approaches (molecular signature using NGS and proteomic).
- Highlight how a research continuum, from basic research to clinical and translational research, provides opportunities to solve human health issues.

The educational objectives are :
- Encourage the students to speak. Students will ensure the moderator role and introduce speakers + elevator speech
- Train students to the evaluation process by awarding themselves the poster price.

The main topics are:
- Basics mechanisms for maintaining genome stability (repair, replication, DNA damage signaling, spatial genome organization)
- Dysfunction of these pathways in human diseases (cancer, aging, immunodeficiency).
- Molecular signature of Genome Instability
- The DNA Damage Response as anti-cancer therapeutic targets and tools for diagnostic/prognostic.

- Career development
- Scientific communication
- Technological workshop
- Poster session
- “Elevator Pitch”
- Students will chair session
- Poster prize

Round table for career development