Mercredi 14 septembre
11 h 00 - 13 h 00

Nuclear Division and Organization

Amphithéâtre Marie Curie
Pavillon Curie, 11 rue Pierre & Marie Curie, Paris 5ème
Conférence en Anglais

My laboratory studies fundamental principles of cell division, using budding yeast as our main model system. We have two major interests. First, we study how chromosome segregation and cytokinesis are coordinated with each other. I will present our recent findings on the Aurora-B-dependent abscission checkpoint (NoCut), which delays completion of cytokinesis in response to anaphase chromatin bridges. In particular, I’ll show that NoCut provides time for chromatin bridge resolution after replicative stress, thus preventing cytokinesis-dependent DNA damage and promoting genome stability. Second, we study how nuclear re-organization is established after asymmetric cell division to regulate cell fate. We discovered an asymmetrically segregated cell fate determinant, the lysine deacetylase Hos3, which is recruited to the periphery of the daughter cell nucleus during mitosis. Hos3 associates with nuclear pores specifically in daughter cells, where it restrains entry into the next cell cycle by multiple mechanisms, including regulation of nucleo-cytoplasmic transport and modulation of gene positioning. Similar mechanisms might establish asymmetries in nuclear organisation and control cell proliferation in multicellular organisms